ABSTRACT
Background: Dexmedetomidine is a highly selective α2adrenergic agonist with an affinity of 8 times greater thanclonidine and hence allows the use of higher doses with lessα1 effect. Hence; the present study was undertaken forassessing the efficacy of Dexmedetomidine under combinedspinal epidural anesthesia.Materials and Methods: A total of 100 patients were enrolledin the present study. All the patients received isobariclevobupivacaine intrathecally and dexmedetomidine in normalsaline epidurally. Complete demographic details and clinicalhistory of all the patients was obtained. Preoperativehematological and biochemical profile of all the patients wasobtained. All the anesthetic procedures were carried out underthe hands of skilled and experienced anesthetists. Incidenceof intra-operative and postoperative adverse events wasrecorded separately. All the results were recorded in Microsoftexcel sheet and were analyzed by SPSS software. Chi- squaretest was used for assessment of level of significance.Results: Mean time taken for sensory regression to S1 was356.12 minutes. Mean time taken for rescue analgesia was362.55 minutes. In the present study, hypotension was foundto be present in 4 patients, bradycardia was found to bepresent in 3 patients and nausea and vomiting was found to bepresent in 5 patients.Conclusion: Dexmedetomidine is an effective agent undercombined spinal epidural anesthesia in patients undergoingelective surgical procedures.